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doi: 10.3233/JAD-2005-7107

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To lessen renal injury, SalB enhances the nuclear accumulation of Nrf2 and suppresses NLRP3 activation, oxidative stress, and Caspase-1/Gasdermin D-mediated cellular pyroptosis via the Nrf2/NLRP3 pathway (Pang et al., 2020)

In those who require 20 h of acetylcysteine, 2 h before completion of acetylcysteine infusion check ALT/AST and paracetamol concentration (in those with high initial paracetamol concentrations greater than double the 150mg at 4 h nomogram line) to determine need for ongoing acetylcysteine