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Currently, Madrigal Pharmaceuticals Rezdiffra, approved in 2024, is the only other FDA-cleared treatment for MASH, as reported by Reuters

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These heterogeneous responses are modulated by multiple factors, including tumor classification, study methodology, treatment duration, and patient-specific parameters (Table 1)

The employment of some mono-functional isoforms of FAD synthase, such as FADS6, has been suggested as an approach for therapy intervention in individuals with FADS defects that do not respond to riboflavin treatment