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Ruan H, Lodish HF

In addition to their roles in bone development and remodeling, osteocytes are also a source of hormonal factors, like FGF23, which modulate mineral homeostasis by acting on distant organs, such as kidney, muscle, parathyroid glands and other tissues (62)

Produced in the hypothalamus, the brains control center for many bodily functions, it causes the pituitary gland to release growth hormone.4 5 Growth hormone, in turn, acts on almost every organ and tissue in two aspects: Physical growth Growth hormone signals the cells in your cartilage and bones to ramp up their replication, especially during adolescence

Atlas of tissue- and developmental stage specific gene expression for the bovine insulin-like growth factor (IGF) system