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2-hydroxyestradiol and 2-methoxyestradiol, the respective products of CYP450 and catechol-O-methyl-transferase from E2 metabolism, have demonstrated increased potency compared to E2 for inhibitory activity of HSCs

Brian Lee, an associate professor of medicine at Keck School of Medicine of USC in Los Angeles, voted no, arguing that the public could view the votes and FDA sign-off as endorsements of the products and that some of the compounds may be no better than a placebo

A deep dive into these mechanisms reveals a multi-faceted approach to healing that addresses inflammation, mucosal damage, and external insults

1 Its also been shown to reverse paralysis induced by agents like succinylcholine, a drug specifically used to temporarily paralyze skeletal muscle during anesthesia