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The choice of site can depend on patient preference, muscle mass, and convenience

You have higher levels of the chemicals homocysteine and methylmalonic acid and reduced DNA synthesis, leading to neurological and psychological symptoms, such as confusion, mood swings, problems walking or talking, and irritability

Phase II Clinical Trials These promising preclinical findings led to Phase I and Phase II clinical trials in humans

Evidence level: Unsupported by the cited record Sources: Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice., Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction., ClinicalTrials.gov exact-name search, accessed 2026-07-12 How to read this: Direct efficacy findings come from obese mice, not human trials