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This disorder is associated with an increased risk for mortality, cardiovascular events, hospitalizations, and intensive care unit admissions [2], and is more common in individuals with chronic kidney disease (CKD) and diabetes treated with guideline-directed medical therapy [3]

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A synergistic action in which glucagon receptor activation enhances energy expenditure whilst GLP-1 receptor agonists reduce calorie intake and both GLP-1/GIP potentiate the incretin effect to modulate the diabetogenic effect of glucagon agonists