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Minocycline, a broad-spectrum antibiotic with anti-inflammatory and antiapoptotic effects (251), is a potential neuroprotective therapeutic compound that may limit BBB dysfunction, preventing TJP disruption through the reduction of microglia's pro-inflammatory cytokines (104) and the inhibition of MMP-9 action

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Dissecting the interdependent effects of stroke, niche-specific effects on adult neurogenesis and nice-specific effects on outcomes, as well as the regional-dependent effects of functional outcomes (sensorimotor or cognitive) creates a prohibitive level of complexity in study design

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