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The primary difference is in their primary area of effect

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In the serum, hydroxocobalamin and cyanocobalamin are believed to function as storage or transport forms of the molecule, whereas methylcobalamin and adenosylcobalamin are the active forms of the coenzyme required for cell growth and replication

One notable finding from animal studies is the unique protein signature observed in EVs from alcohol-fed mice, which reflects inflammatory responses, cellular development and cell migration compared with control EVs.120 When EVs from alcohol-exposed mice were transferred to hepatocytes from mice without alcohol exposure, there was an increased expression of monocyte chemoattractant protein 1 mRNA and protein, suggesting that these EVs play a direct role in promoting liver inflammation and injury.120 Additionally, mice receiving EVs from alcohol-fed counterparts displayed significant alterations in the populations of KCs and infiltrating monocytes.120 Specifically, there was an increase in pro-inflammatory F4/80 hi CD11b lo KCs, which are typically associated with an inflammatory phenotype.120 This shift was further characterised by an elevated percentage of TNF- + /IL12/23 + KCs and monocytes, indicative of a pro-inflammatory (M1) state, while the percentage of anti-inflammatory (M2) KCs decreased.120 This study illustrated how alcohol-derived EVs skew the immune balance towards a more inflammatory environment in the liver