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All these phase I metabolites have oxidative, or damaging, potential

Timing Protocols : Some research suggests that administration timing relative to meals or exercise may influence both effectiveness and side effect profiles

Methodology: new derivatives with benzamide nucleus were designed carefully, underwent energy minimization, and then docked using the Genetic Optimization of Ligand Docking (GOLD)

2 Department of Neurology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450052, Peoples Republic of China *These authors contributed equally to this work Correspondence: Jian Wang