Without robust clinical trials in breastfeeding populations, conservative medical practice recommends avoiding GLP-1 medications during active nursing, particularly during the first 6 months when infants are most vulnerable to systemic drug exposure
Systemic effects that have been reported in trials, or that are mechanistically expected from elevated GH and IGF-1, include: Water retention and mild edema , particularly in the hands, ankles, and face Tingling, numbness, or 'pins and needles' (paresthesia) , sometimes linked to fluid pressure on nerves Headache and facial flushing , often shortly after administration Joint aches or stiffness (arthralgia) Transient changes in blood glucose due to GH's counter-regulatory effect on insulin Fatigue, dizziness, or a feeling of light-headedness in some individuals It is important to be candid about the limits of this evidence
They can assess whether the medication should be replaced and arrange a new prescription if necessary
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