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NF-B is the pathway regulating endothelium-leukocyte interactions by adhesion molecules, such as intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin (49)

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is between 2.3 and 10.3 people per 100,000 individuals per year, resulting in approximately 6,000 new NAION cases each year, making it the most common cause of acute optic neuropathy in patients over the age of 50

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