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Glutathione peroxidase (GPx) serves as another essential antioxidant enzyme in sperm, playing a pivotal role in neutralizing hydrogen peroxide and lipid hydroperoxides, which arise when ROS target polyunsaturated fatty acids (PUFAs) in the sperm membrane (99, 100)

The Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results trial (LEADER) led to a paradigm shift in the wider use of GLP-1RA from promising antihyperglycemic agents to cornerstone cardiometabolic therapies, demonstrating the significant reduction of major adverse cardiovascular events (MACE) with the use of liraglutide in the population with type 2 diabetes mellitus (T2DM) [12, 13]

Taking a double dose to make up for a missed one can increase the risks of side effects

Topiramate is not a controlled substance, but it carries its own regulatory requirements, including the REMS (Risk Evaluation and Mitigation Strategy) program that Qsymia must follow due to the risk of birth defects