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In fact, human recombinant HGF (hHGF) and hHGF gene therapy (Collategene, a hHGF DNA plasmid) have been examined as a treatment option in several intractable diseases, such as amyotrophic lateral sclerosis, hepatic cirrhosis and peripheral arterial disease 11,12

requires medical knowledge to minimize risk Intranasal Intranasal delivery to target the olfactory bulb and trans-cribriform access to the brain has been explored for some peptides: Theoretical advantage: Direct CNS access, bypassing the blood-brain barrier Reality: Intranasal peptide formulations are complex and Dihexa is not commonly available in this form Evidence: No published data on intranasal Dihexa efficacy or safety Oral Bioavailability: Approximately 38% The most commonly cited bioavailability figure for oral Dihexa is approximately 38%

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Most users can progress to 300 mcg daily after the first two weeks