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doi:10.1161/01.CIR.96.3.1031

Notably, many if not most, gains of potentially detrimental effects come about through the loss or malfunction of physiological astrocytic processes, rather than through the activation of pre-programmed and intentionally toxic mechanisms

suggest that this may translate into the peptides potential for induction of metallo-proteinases, chemotaxis, angiogenesis and [mitigation] of inflammation as well as the [mitigation] of bone marrow stem cell proliferation

Note that we need to compute and analyze the second derivative to understand concavity, so we may as well try to use the second derivative test for maxima and minima