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Rough handling, incorrect temperatures, or the wrong diluent can denature this structure, essentially breaking it and rendering it useless
However, because the body is so efficient at regulating these levels, "more" is not always "better." This is why we focus on bioavailability rather than just high milligrams
The decision about which medication to adjust first should be made by the prescribing clinician based on the patient's comorbidities, indications for specific medications (such as nephroprotection), and adverse effect profiles
PMID 15277417
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