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Caution: Some people notice an aftertaste or mild digestive sensitivity

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Interestingly, these pharmacological concentrations align closely with peak levels of endogenous GLP-1 observed during intense physiological stimulation [120, 121]

Particularly for heart failure, several clinical trials and meta-analyses have already confirmed that SGLT2is reduce HHF by approximately 30% in both HFrEF and HFpEF, with or without diabetes [46]