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Contrasted with the short-term treatment duration group, the long-term treatment group had an increased risk of total adverse reactions (RR 110, 95% CI 105 to 114), vomiting (RR 430, 95% CI 345 to 537) and discontinuation (RR 182, 95% CI 142 to 233), see Figure 4 ( Tables S2022 )

The preservative (if used) may be ineffective to inhibit microbial growth and cause sterility problems Patient Implication: A patient may be dispensed a 10 mL bottle of semaglutide with a BUD of 30 days

The legal status of GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists varies considerably across international jurisdictions, and patients must research specific requirements for their destination countries

Headache: Some individuals report mild headaches during the peak concentration period