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Schuppan, D., Ruehl, M., Somasundaram, R

People who take CONTRAVE must not use any type of opioid, including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, for at least 7 to 10 days before starting CONTRAVE

Because the medication significantly amplifies satiety signals, eating past the first indication of fullness can quickly produce significant discomfort

Underline the necessity for a pre-dose fasting condition (enough to have an empty stomach) and observing an additional fasting period of at least 30 min post-dose, along with avoiding pharmacological interactions to allow correct semaglutide absorption