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Digoxin (14, 29) Digoxin (14, 29) Class: Antiarrhythmics Use: Treat heart failure and abnormal heart rhythms (arrhythmia) Mechanism of Action: Direct suppression of the AV node conduction to increase the effective refractory period and decrease conduction velocity, leading to a positive inotropic effect, enhanced vagal tone, and decreased ventricular rate to fast atrial arrhythmias (29)

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Science 257: 14961502 JessopCE,BulleidNJ (2004) Glutathione directly reduces an oxidoreductase in the endoplasmic reticulum of mammalian cells

Vitamin A (retinol) downregulates the receptor for advanced glycation endproducts (RAGE) by oxidant-dependent activation of p38 MAPK and NF-kB in human lung cancer A549 cells