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"A rapid reduction in fat can cause skin to sag, accentuating features associated with aging, such as jowls, loose skin on the neck and a sunken appearance around the eyes." Though not everyone on a GLP-1 will experience skin sagging, according to a recent article from the Cleveland Clinic, "the faster you lose weight, the more likely you are to experience" facial skin sagging

Other adherence studies suggest oral semaglutide can perform similarly to established oral therapies and, in some groups, may show better persistence than injectable semaglutide over 12 months (source)

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This can intensify nausea and reflux, particularly during initial treatment weeks or after dose increases