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And in a 2022 study of people with treatment-resistant bipolar depression, participants depression and functioning improved upon the reversal of insulin resistancea metabolic condition that is more common in people with bipolar disorder (J

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clinician determines final eligibility Who shouldn't apply: Personal or family history of medullary thyroid carcinoma or MEN 2 syndrome, history of pancreatitis, certain severe GI or kidney conditions, pregnancy, or breastfeeding - clinician screens at intake FDA regulatory status as of June 2026: Active enforcement and regulatory change ongoing