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Although some of these appearances are probably smearing artifacts, electron micrographic evidence suggests that in some of the cells, opposing surfaces of the membrane have become cross-linked. Probably the most characteristic poikilocytes are those in which the cell margin literally appears dented, as though a portion has been plucked out or bitten away (bite cells

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doi: 10.1371/journal.pone.0111265 70 HolickMF

The study did not include neurodevelopmental disorders other than autism limiting the understanding of the specificity of biomarkers and metabolic states