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3.3 Results: direct detection of ROS in CF 3.3.1 Superoxide anion Early investigations into the oxidative burst mechanisms in CF revealed notable differences in immune cell activity, even among carriers of a single CFTR mutation (heterozygotes)

Using data from the European Registration of Congenital Anomalies and Twins (EUROCAT) database, a case-control study, involving 596 cases and 2,359 controls, found that consumption of at least 400 g/day of folic acid during the periconceptual period (one month before conception through eight weeks' post-conception, covering the period of embryonic heart development) was associated with an 18% reduced risk of congenital heart defects (59)

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It was used to identify the HCV genotype and subtype in 516 treatment-nave patients included in a multicenter clinical trial assessing different schedules of pegylated IFN-2a and ribavirin [26]