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Dysregulation is a hallmark of both chronic wounds and photoaged skin models

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You're more likely to get melanoma if you have: Symptoms If your melanoma has spread to other areas, you may have: Hardened lumps under your skin Swollen or painful lymph nodes Trouble breathing, or a cough that doesn't go away Swelling of your liver (under your lower right ribs) or loss of appetite Bone pain or, less often, broken bones Headaches, seizures, or weakness or numbness in your arms or legs Weight loss Fatigue Getting a Diagnosis Before you have any tests, your doctor will want to know: If you havent already been diagnosed with melanoma, your doctor will do a skin exam

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