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Journal : Cell Metabolism Year : 2008 DOI : Plasma acylcarnitine prooiling indicates mitochondrial dysounction in diabetes Adams, S.H., Hoppel, C.L., Lok, K.H., et al

The mechanism is dose-dependent but not inevitable

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Nevertheless, deficiency or oxidation of L-arginine and tetrahydrobiopterin (BH 4 ), which are two essential cofactors for eNOS action, are associated with the uncoupling of the L-arginine-NO pathway that results in the decreased formation of NO and increased eNOS-mediated generation of superoxide