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It could be a trailblazer in a class of triple-agonist drugs and demonstrate the value of targeting multiple gut hormones simultaneously

Through the production of metabolites such as short-chain fatty acids, indole derivatives, and bile acidrelated molecules, and via receptor pathways including FFAR2/3, FXR, and TGR5, the microbiota modulates incretin secretion, tissue insulin sensitivity, immune tone, and the integrity of the intestinal epithelial barrier