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Methods Study design and participants The protocol of the clinical trial was registered on March 6, 2020 (Clinicaltrials.gov

These findings align with global analyses from Europe, North America, and Asia reporting similar population-level increases in vitamin B12 deficiency, where prevalence ranges from 5 to 20% depending on age, diet, and socioeconomic status

Additionally, managing stress and getting enough sleep can promote overall well-being, which may indirectly benefit vitamin B12 status

Although more research is needed to establish definitive protocols, the theoretical framework and emerging evidence suggest that this combination may enhance outcomes for patients struggling with metabolic disorders