Plasminogen activator inhibitor-1 (PAI-1) is the body primary brake on clot dissolution
Ideal candidates for GHK-Cu before and after transformations, based on published research and user reports, include: People in their 30s and early 40s are noticing the first signs of aging People with photoaged or sun-damaged skin People with sensitive, reactive, or rosacea-prone skin People recovering from microneedling, lasers, or peels People dealing with hyperpigmentation, melasma, or acne marks People with early-to-moderate hair thinning People in their 50s and beyond focused on maintenance First-time peptide users looking for a gentle starting point Severe deep wrinkles, advanced sagging, significant volume loss, and fully dead hair follicles wont respond significantly
Baron doesnt advocate for those with Wilson's disease using copper peptides of any sort (GHK-Cu included), as this genetic condition causes the body to hold onto too much copper
Afamelanotide (Nle-D-Phe--MSH) is MC1R-preferring and used in protoporphyria research because its selectivity limits off-target effects in the central nervous system
