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Moreover, the C-terminal serine of the peptide was replaced by cysteine via site-directed mutagenesis performed with polyethylene glycol

This strategy allows for an increased delivery of active agent to the tumor tissue, while minimizing the toxicity toward normal tissues

Factors like the specific peptide, dosage, frequency of use, and individual susceptibility can influence the potential for developing a dependency on peptides

Writers, erasers, and readers are three pivotal regulatory enzymes in this process, managing the addition of lactylation modifications, the elimination of lactyl groups, and their spatial distribution