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\n\n\n\n Preclinical studies have reported no significant toxic, mutagenic, or carcinogenic effects at research amounts in short- to medium-term rodent studies

J Clin Endocrinol Metab 1992;75:8129.ArticlePubMed 37

44 excessive NO release can lower LES pressure, while Ach dysfunction reduces gastrointestinal peristalsis

A woman can gain relatively little weight on the scale yet experience significant metabolic deterioration if that weight is concentrated in the abdominal area