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One further nuance worth noting: the addition of GIP in both tirzepatide and retatrutide is hypothesised to improve gastrointestinal tolerability relative to GLP-1 alone at comparable efficacy

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For instance, in a placebo-controlled study of 24 obese patients with T2DM, exenatide treatment for 12 weeks exerted an anti-inflammatory effect independent of body weight reduction, as illustrated by reduced circulating levels of various pro-inflammatory mediators such as TNF-, IL-1, IL-6, serum amyloid A, and MMP-9 [79]