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Circulation 136 , 12331246 (2017)

Constante M, Fragoso G, Lupien-Meilleur J, Calv A, Santos MM

In fact, studies in animal models imply that long-term delivery of nerve growth factors could protect against programmed cell death in these conditions

In their head-to-head research models, Ipamorelin produced: Robust GH release comparable in magnitude to the older GHRPs No significant cortisol elevation versus baseline or control comparators No significant prolactin elevation versus baseline or control comparators No significant aldosterone elevation versus baseline or control comparators This is what "selectivity" means in this research context: the compound produces the desired effect (GH release through the ghrelin receptor pathway) without producing the off-target effects (cortisol, prolactin, aldosterone) that related compounds did