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On the other hand, vildagliptin and saxagliptin act through a biphasic inhibition process, beginning with the formation of a reversible covalent enzymeinhibitor complex, followed by slow dissociation

These treatments are delivered through a safety-first methodology that includes structured patient care and clear escalation pathways

Consistent with adiponectins insulin-sensitizing function, lower adiponectin level has been observed in obese and diabetic populations [10, 11], suggesting a reverse correlation between the adiponectin level and insulin sensitivity