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As alluded to above, calcitonin mediates its effects via the 7-transmembrane calcitonin receptor and a subsequent increase in intracellular cAMP ( via inhibition of osteoclasts ( Figure 1 ) ( Calcitonin in Metabolic Disease It is difficult to evaluate the role of endogenous calcitonin in metabolic diseases for a number of reasons: 1) only few studies have applied human calcitonin in humans, 2) there are currently no antagonists available which selectively target the monomeric calcitonin receptor ( Amylin and Calcitonin-Based Pharmacotherapies Pramlintide Pramlintide is a Food and Drug Administration (FDA)-approved amylin analogue, developed for individuals with type 1 diabetes or insulin-treated type 2 diabetes as an adjunct therapy to mealtime insulin (92)