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PAP blocks the NF-B signaling pathway to downregulate the expression of pro-inflammatory cytokines such as TNF- and IL-6, inhibiting the neuroinflammatory cascade, while also inhibiting the hypoxia stress signals mediated by HIF-1, reducing abnormal secretion of VEGF, thereby decreasing vascular permeability and the risk of brain edema (Shi J

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[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Waijer SW, Vart P, Cherney DZ, Chertow GM, Jongs N, Langkilde AM, et al

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