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The high density of mitochondria provides numerous targets for copper binding to lipoylated TCA cycle enzymes, directly disrupting the energy supply vital for contraction [75]

Among these, long-term use of macrolide antibiotics has been proven to reduce acute exacerbation occurrence risk, but this treatment strategy also brings potential problems of antibiotic resistance and drug adverse reactions ( DPP1 inhibitors have clear potential advantages in bronchiectasis treatment

The retatrutide dosing protocol reflects this triple mechanism

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