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Ferrostatin 1 (Fer1), a known ferroptosis inhibitor, was used for co-treatment experiment and abrogated RSL3-mediated lipid peroxidation in PTC cells

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To modify antioxidants in therapy, strategies include targeting GPX4 activity, manipulating GSH levels, optimizing exogenous antioxidants, and exploiting Nuclear factor erythroid 2related factor 2 (NRF2) pathways [254]

403,404 Additionally, TCMs play pivotal roles in HAPH prevention: Danshensu , 405 Oxymatrine , 406 Salvia Przewalskii Maxim , 407 and Hydroxysafflor Yellow A 408 mitigated HPVR and right ventricular hypertrophy by suppressing inflammatory responses and PASMCs proliferation