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Notably, semaglutide significantly increased the likelihood of achieving a 2-level reduction in WHO risk drinking level, a clinical trial endpoint recently qualified by the US Food and Drug Administration (FDA), with a number-needed-to-treat of 4.3 suggesting potentially greater efficacy relative to existing alcohol use disorder medications. (!) They see practical applications: GLP-1 therapies could prove effective for reducing drinking levels in mild or prodromal alcohol use disorder, perhaps offering a treatment that can be delivered in primary care. Christian S

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