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Nrf2 is a major regulator of the cellular oxidative stress response and maintenance of redox homeostasis ( 2.3 Cisplatin induces mitochondrial dysfunction When cisplatin enters the mitochondria, it acts directly on the inner mitochondrial membrane, leading to the impairment of the function of the electron transport chain, the reduction of ATP production and the induction of ROS generation ( Dysfunctional mitochondria release into the cytoplasm, it binds to with Apaf-1, triggering caspase-9, caspase-3 related cascade reactions that lead to apoptosis (Figure 2)

Pterostilbene Commonly found in blueberries, pterostilbene is a well-studied antioxidant with the potential to prevent and treat various medical conditions.13 It doesnt appear to have a role in NAD+ synthesis, though, and Elysium Basis is the only product in the space to include pterostilbene

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