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Although there are undoubtedly more details to unravel regarding the mechanisms of action of metformin, the work by Maida et al

To prolong plasma half-life and improve drug delivery, butyrate and sorafenib were co-encapsulated within antibody-functionalized mPEG-PLGA-PLL nanoparticles, which significantly reduced sorafenib-induced liver injury and suppressed hepatocellular carcinoma progression [121]

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Therefore, ensuring adequate levels of other key antioxidants can also support glutathione levels