high cholesterol and glp-1 Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism Beyond the Cardiovascular Effects of

FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes

Summary statistics on baseline characteristics by arm were used to assess risk of bias from loss of randomisation

How to Support Your Body During Withdrawal Nutrition & Appetite Management Keep healthy, filling foods in the house Plan meals in advance Eat slowly, using smaller plates Stop eating when youre about 80% full Pause 20 minutes before going for seconds Stay hydrated and identify emotional vs physical cravings Blood Sugar Management (for those with diabetes) Check levels more frequently during the first month Stick to a regular eating routine Balance carbs with protein and healthy fats Be ready to adjust your other diabetes medications Weight Management Tips Know that some weight regain is normal Focus on sustainable habits, not just the number on the scale Celebrate non-scale victories: energy, sleep, strength Keep moving: aim for at least 150 minutes of activity a week Mental Health & Support Be kind to yourselfthis is a transition Talk to a counsellor or join a support group if needed Use healthy coping strategies for stress Focus on overall health , not just weight Alternative Options and Next Steps Other Weight Management Medications (UK-Approved) Orlistat (available as Alli over the counter) Works by reducing fat absorption in the gut

Cohen P, Cross D, Janne PA