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Abbreviations AT: As-treated CEA: Cost-effectiveness analysis CPI: Consumer price index CVD: Cardiovascular disease GDP: Gross domestic product GLA: Glucose-lowering agent GLP-1RA: GLP-1 receptor agonist HR: Hazard ratio ICER: Incremental cost-effectiveness ratio ITT: Intention-to-treated MACE: Major adverse cardiovascular event NHI: National Health Insurance NHIRD: National Health Insurance Research Database NNT: Number needed to treat OOP: Out-of-pocket QALY: Quality-adjusted life year T2D: Type 2 diabetes WTP: Willingness-to-pay References American Diabetes Association

Tirzepatide's dual action on two hormone pathways may offer an additive effect, potentially leading to more significant weight loss than semaglutide

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For example, microspherocytosis in autoimmune hemolytic anemia, macro-ovalocytes in MA, etc