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Activation of GHRH-R adenylate cyclase increased intracellular cAMP activation of PKA phosphorylation of the transcription factor CREB increased transcription of the GH gene increased intracellular GH stores in vesicles

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The control group showed a smaller reduction (p = 0.006), with a standardized mean difference of 0.695 kg/m 2 at 6 months and 0.758 kg/m 2 at 1 year