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Approved GLP-RAs In 2005, Exendin-4 (Exenatide/ BYETTA), the world's first GLP-1RA, was approved by the FDA for the adjuvant treatment of type 2 diabetes with two injections per day (BID)

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Metformin Metformin is widely known for its use in managing type 2 diabetes but also plays a role in weight loss