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The molecule contains a cysteine-linked disulfide bridge that constrains the peptide into a cyclic conformation, an important feature for maintaining its signaling profile in biochemical and adipocyte-based assays

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However, it also turns out to be true that, under normal conditions, dietary intake of glutathione does not allow its direct use: since it is a tripeptide, enzymes in the gastric juices would break it down into its constituent amino acids, forcing our body to consume energy to synthesize it from scratch