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We also showed that GLP-1 protects beta cells from apoptosis in part through PKA and PI3K-dependent pathway, which are consistent with previous results 19,20,21 (see model in Fig

In this review, we first summarize the principles and fabrication strategies underlying OoC technology, then trace their evolution toward autologous systems capable of modeling autoimmune diseases and assessing drug efficacy and safety in a translationally relevant manner