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All pairings should follow validated protocols with appropriate controls

Ceftriaxone has been shown to reduce the symptoms of BIPN, indicating that regulating glutamate homeostasis could represent a promising therapeutic strategy (Robinson and Dougherty, 2015)

RM-718 and PL7737 are also selective away from MC1R and should mitigate increases in skin pigmentation

Induction of this biosynthetic pathway enhances intracellular GSH levels and promotes cancer cell resistance to ferroptosis, 142,143 whereas pharmacological inhibition of GSH synthesis by L-buthionine-(S,R)-sulfoximine (BSO), a GCL inhibitor, induces ferroptosis 144