In 2017, Neelakantan and colleagues first systematically characterized 5amino1mq during screening for selective NNMT inhibitors, with findings published in Biochemical Pharmacology - marking the official discovery and public reporting of the compound.Through structural modification of quinolinebased precursors, the team identified 5amino1mq as a small, membranepermeable molecule with the chemical formula CHN.With an extremely low IC value, it became one of the most promising selective NNMT inhibitors available at the time, with high specificity and no significant inhibition of other metabolically relevant enzymes
In sharp contrast, normalized debutyrylation efficiencies at H3K9 by Sirt7 were 0.240.48, suggesting that Sirt7 did not efficiently debutyrylate H3K9 compared to H3K18, which is consistent to the previous report showing Sirt7 as a deacetylase for H3K18 35
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