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The hard part

[DOI] [PubMed] [Google Scholar] 58.Marciniak A., Szydlowska I., Brodowska A., Wisniewska B., Nawrocka-Rutkowska J., Starczewski A

Both exenatide and lixisenatide are contraindicated in patients with eGFR 6.5% for patients with concurrent serious illness and at risk of hypoglycaemia progression c Typical osmotic or catabolic symptoms of diabetes mellitus The usefulness of GLP-1 analogues in glycaemic control with low risk of hypoglycaemia and body weight reduction has been taken into consideration in all the guidelines listed in Table 9

Neither peptide "stays local" both enter systemic circulation within minutes but local injection may give a higher first-pass tissue concentration before that dilution. Safe placement matters more than a perfect site: for hard-to-reach injuries (spine, deep hip), abdomen or thigh works