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Translational concordance is strong: zebrafish SLC52A3 knock-down and SLC52A3 / mice recapitulate hearing loss, ataxia and early death, all of which improve with systemic riboflavin supplementation (17, 18)

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Dosage, Concentration, Route of Administration Dosage : Seek advice from an appropriately qualified and licensed physician, medical director, or other healthcare provider Concentration : 2mg/ml Route of Administration : IV/IM/SQ Resources: Precautions/Side Effects Hydroxocobalamin injections are contraindicated in people with low blood potassium or allergies to vitamin B12 or cobalt

REW enhances complement activation in an on-target manner Our structure-based approach did not only aim to improve engagement of human FcRn, but also the capacity to form Fc:Fc interactions in an on-target manner to facilitate hexamer Fc formation and complement activation 40 (Fig